Cowboys co-captain Michael Morgan has been ruled out of Sunday's clash against the Titans due to a shoulder injury.
Morgan pulled up sore after last weekend's clash and has not improved throughout the week, though North Queensland are hopeful he will only miss one game with the issue and return in round four.
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Here is all the latest round-three selection news, predicted teams and injury updates.
Cowboys v Titans, Sunday 6.15pm at Queensland Country Bank Stadium
Cowboys: A late reshuffle in the backline with Valentine Holmes moving to his preferred fullback position and Scott Drinkwater moving to five-eighth with Ben Hampton dropping out. Shane Wright was the other player to drop out and hour before kick-off.
Justin O'Neill has come off the reserves list to play wing in jersey 18.
Michael Morgan (shoulder) and Peter Hola were omitted on Saturday.
Second-rower Coen Hess suffered a burner injury against the Dragons but will play.
Murray Taulagi will replace suspended winger Kyle Feldt, who copped a two-week ban for his tackle on Dragons centre Jack Bird.
Payten elected to stick with Reuben Cotter at No.13 as forward leader Jason Taumalolo's (broken hand) replacement despite a spirited challenge from veteran Josh McGuire. Cotter was the team's Players' Player against St George Illawarra.
The Cowboys have won 10 of their past 11 games against the Titans.
Titans: Tyrone Peachey has been brought into the starting side at lock with Tino Fa'asuamaleaui shifting to prop and Moeaki Fotuaika to the bench.
Beau Fermor and Sam Stone were omitted an hour before kick-off.
A hand injury has sidelined five-eighth Ash Taylor for at least a few weeks. Tanah Boyd will make his second start at No.6 in Taylor's place.
Phillip Sami will continue to deputise in the centres with Brian Kelly (fractured hand) scheduled to return in round five.
Herman Ese'ese and Sam McIntyre dropped out of the squad 24 hours before kick-off.
The Titans have not won in Townsville since 2012.